The Calvinist doctrine of total depravity holds that man is unable to believe the gospel and must be regenerated before he can. It makes the gospel of little worth.
However
John 3:14–21 (NASB95) — 14 “As Moses lifted up the serpent in the wilderness, even so must the Son of Man be lifted up; 15 so that whoever believes will in Him have eternal life. 16 “For God so loved the world, that He gave His only begotten Son, that whoever believes in Him shall not perish, but have eternal life. 17 “For God did not send the Son into the world to judge the world, but that the world might be saved through Him. 18 “He who believes in Him is not judged; he who does not believe has been judged already, because he has not believed in the name of the only begotten Son of God. 19 “This is the judgment, that the Light has come into the world, and men loved the darkness rather than the Light, for their deeds were evil. 20 “For everyone who does evil hates the Light, and does not come to the Light for fear that his deeds will be exposed. 21 “But he who practices the truth comes to the Light, so that his deeds may be manifested as having been wrought in God.”
Mark 6:12 (LEB) — 12 And they went out and proclaimed that people should repent.
To command men, “Bring forth therefore fruits worthy of repentance” (Lk. 3:8; Matt. 3:8), and to tell them to “repent and turn to God, and do works meet for repentance” (Acts 26:20), both implies that it is man’s choice, man’s responsibility, and within man’s ability or control to repent and bring forth fruits from that repentance. If it were not, it would make no sense to command them to do so.
The disciples of the Lord “went out, and preached that men should repent” (Mark 6:12). This takes for granted that repentance is a choice, specifically man’s choice, and that man can make that choice. God’s invitation to come is for all men (Matt. 11:28). As the Bible says “Go ye therefore into the highways, and as many as ye shall find, bid to the marriage” (Matt. 22:9). Jesus also said to the Church, “Go ye into all the world, and preach the gospel to every creature” (Mark 16:15). Why should we preach the gospel to all men, commanding them to repent and believe, unless all men are capable of this? It would be a waste of time and energy to call and command men to do that which they cannot do.